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From evolutionary bystander to master manipulator: the emerging roles for the mitochondrial genome as a modulator of nuclear gene expression

Median body mass index (BMI) was 23.2 kg/m 2 (IQR, 21.2 to 25.4) and all but one patient had T2DM

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Originally approved for people with type 2 diabetes, several GLP-1 receptor agonists now have FDA indications for weight management, including once-weekly injectable semaglutide 2.4 mg (Wegovy, Novo Nordisk) and tirzepatide (Zepbound, Eli Lilly), an injectable GIP/GLP-1 dual incretin-based agonist

The features we observe are largely consistent with other ABCC structures 22,26,27

2011;342:d2218